Publications

Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.
Chang, J., Mancuso, M. R., Maier, C., Liang, X., Yuki, K., Yang, L., Kwong, J. W., Wang, J., Rao, V., Vallon, M., Kosinski, C., Zhang, J. J., Mah, A. T., Xu, L., Li, L., Gholamin, S., Reyes, T. F., Li, R., Kuhnert, F., Han, X., Yuan, J., Chiou, S., Brettman, A. D., Daly, L., Corney, D. C., Cheshier, S. H., Shortliffe, L. D., Wu, X., Snyder, M., Chan, P., Giffard, R. G., Chang, H. Y., Andreasson, K., Kuo, C. J. Nat Med 2017; 23 (4): 450-460. doi: 10.1038/nm.4309. Epub 2017 Mar 13.

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.
Woodling, N. S., Colas, D., Wang, Q., Minhas, P., Panchal, M., Liang, X., Mhatre, S. D., Brown, H., Ko, N., Zagol-Ikapitte, I., Van der Hart, M., Khroyan, T. V., Chuluun, B., Priyam, P. G., Milne, G. L., Rassoulpour, A., Boutaud, O., Manning-Bog, A. B., Heller, H. C., Andreasson, K. I. Brain 2016; 139: 2063-2081. doi: 10.1093/brain/aww117. Epub 2016 May 13.

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease. 
Mhatre, S. D., Tsai, C. A., Rubin, A. J., James, M. L., Andreasson, K. I. Trends in neurosciences. 2015 38 (10): 621-636. doi: 10.1016/j.tins.2015.08.006. 

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models
Johansson, J. U., Woodling, N. S., Wang, Q., Panchal, M., Hang, X., Trueba-Saiz, A., Brown, H. D., Mhatre, S. D., Loui, T., Andreasson, K. I. J Clin Invest. 2015; 125 (1): 350-364. doi: 10.1172/JCI77487

Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.
Woodling NS, Wang Q, Priyam PG, Larkin P, Shi J, Johansson JU, Zagol-Ikapitte I, Boutaud O, Andreasson KI. J Neurosci. 2014 Apr 23;34(17):5882-94. doi: 10.1523/JNEUROSCI.0410-14.2014.

Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia.
Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI. J Neurosci. 2013 Oct 2;33(40):16016-32. doi: 10.1523/JNEUROSCI.2203-13.2013.

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.
Shi, J., Wang, Q., Johansson, J. U., Liang, X., Woodling, N. S., Priyam, P., Loui, T. M., Merchant, M., Breyer, R. M., Montine, T. J., Andreasson, K. Annals of Neurology 2012; 72 (5): 788-798.

Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of beta-Amyloid in T(H)1 and T(H)17 Versions of Experimental Autoimmune Encephalomyelitis.
Grant, J. L., Ghosn, E. E., Axtell, R. C., Herges, K., Kuipers, H. F., Woodling, N. S., Andreasson, K., Herzenberg, L. A., Herzenberg, L. A., Steinman, L. Sci Transl Med 2012; 4 (145)

Signaling via the prostaglandin E2 receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia.
Liang X, Lin L, Woodling NS, Wang Q, Anacker C, Pan T, Merchant M, Andreasson K. J Clin Invest. 2011; 121 (11): 4362-71

Emerging roles of PGE2 receptors in models of neurological disease.
Andreasson K, Prostaglandins Other Lipid Mediat. 2010; 91 (3-4): 104-12

The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity.
Shi J, Johansson J, Woodling NS, Wang Q, Montine TJ, Andreasson K. J Immunol. 2010; 184 (12): 7207-18

The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis.
Liang X, Wang Q, Shi J, Lokteva L, Breyer RM, Montine TJ, Andreasson K. Ann Neurol. 2008; 64 (3): 304-14

Cyclooxygenase-dependent lipid-modification of brain proteins.
Boutaud O, Andreasson KI, Zagol-Ikapitte I, Oates JA. Brain Pathol. 2005; 15 (2): 139-42

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.
Liang X, Wang Q, Hand T, Wu L, Breyer RM, Montine TJ, Andreasson K. J Neurosci. 2005; 25 (44): 10180-7

PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosis.
Bilak M, Wu L, Wang Q, Haughey N, Conant K, St Hillaire C, Andreasson K. Ann Neurol. 2004; 56 (2): 240-8

Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.
McCullough L, Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM, Andreasson K. J Neurosci. 2004; 24 (1): 257-68

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