Advancing the Neuroscience and Clinical Applications for Brain Performance
Pac-12 Student-Athlete Health & Well Being Initiative
The Pac-12 Initiative is a collective effort between the Conference and member universities to find ways to reduce injuries, share current best practices and latest studies, and conduct research to uncover new ways to keep student-athletes as safe as possible. In 2019, the Pac-12 Grant Program committed funding to Dr. Angela Lumba-Brown for leading a study, "The Subtypes of Concussion - Classification and Recovery Trajectories in Pac-12 Student Athletes," aimed at advancing the science of concussion care and changing how concussions are diagnosed and managed.
Brain Trauma Evidence-Based Consortium (B-TEC)
Launched in 2014 with funding by the U.S. Department of Defense to Stanford University, and subcontracted to the Brain Trauma Foundation, B-TEC brings together brain injury experts from the Brain Trauma Foundation, Stanford University, Oregon Health and Sciences University, and Portland State University. The Consortium's aim is to develop an evidence-based classification for the spectrum of traumatic brain injury, including concussion, and to model post-injury trajectories and outcomes.
Core Objectives:
1. To establish evidence for concussion subtypes, describing their prevalence in head injured patients, and informating how each subtype recovers. Goals of this work are to lead to targeted management strategies to effect better care.
2. To maximize the utility of scientific effortrs to-date that address the epidemic of concussion and brain trauma, for the purpose of deriving a clinically useful classification system, and evidence-based guidelines for diagnosis, prognosis, treatment, and outcomes.
3. To create a consortium among the neurotrauma community that will inspire a commitment to the principles of evidence-based medicine in the design and conduct of brain trauma research.
4. To continue updating the Brain Trauma Foundation traumatic brain injury guidelines.
Key Research Areas:
- Concussion Subtypes
- Sports-related Concussion
- Head Injury in Children
- Classification of Severe Traumatic Brain Injury
- Pediatric Management of Severe Traumatic Brain Injury
- Adult In-Hospital Management of Severe Traumatic Brain Injury
- Pre-Hospital Management of Severe Traumatic Brain Injury in Adults and Children
- Brain Injury Algorithm Development
Founded by Center Director, Dr. Jamshid Ghajar, in 1986, the Brain Trauma Foundation was created to provide ongoing support for research on TBI. In the three decades since its founding, the Foundation continues to focus on conducting innovative clinical research, updating evidence-based guidelines, and working towards improving outcomes for the millions of people who suffer from traumatic brain injuries every year.
Landmark Research
September 2020
Sex-Related Differences in Neurosensory Alterations Following Blunt Head Injury
Angela Lumba-Brown, Kian Niknam, Jordan Cornwell, Courtney Meyer, Jamshid Ghajar
Frontiers in Neurology. 2020; Volume 11; doi:10.3389/fneur.2020.01051
September 2020
Guidelines for the Management of Severe Traumatic Brain Injury: 2020 Update of the Decompressive Craniectomy Recommendations
Gregory W J Hawryluk, MD, PhD, FRCSC, Andres M Rubiano, MD, Annette M Totten, PhD, Cindy O'Reilly, BS, Jamie S Ullman, MD, Susan L Bratton, MD, Randall Chesnut, MD, Odette A Harris, MD, MPH, Niranjan Kissoon, MD, Lori Shutter, MD, Robert C Tasker, MBBS, MD, Monica S Vavilala, MD, Jack Wilberger, MD, David W Wright, MD, Angela Lumba-Brown, MD, Jamshid Ghajar, MD, PhD
Neurosurgery. 2020;87(3):427-434. doi:10.1093/neuros/nyaa278
May 2020
A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)
Randall Chesnut, Sergio Aguilera, Andras Buki, Eileen Bulger, Giuseppe Citerio, D Jamie Cooper, Ramon Diaz Arrastia, Michael Diringer, Anthony Figaji, Guoyi Gao, Romer Geocadin, Jamshid Ghajar, Odette Harris, Alan Hoffer, Peter Hutchinson, Mathew Joseph, Ryan Kitagawa, Geoffrey Manley, Stephan Mayer, David K Menon, Geert Meyfroidt, Daniel B Michael, Mauro Oddo, David Okonkwo, Mayur Patel, Claudia Robertson, Jeffrey V Rosenfeld, Andres M Rubiano, Juan Sahuquillo, Franco Servadei, Lori Shutter, Deborah Stein, Nino Stocchetti, Fabio Silvio Taccone, Shelly Timmons, Eve Tsai, Jamie S Ullman, Paul Vespa, Walter Videtta, David W Wright, Christopher Zammit, Gregory W J Hawryluk.
Intensive Care Med. 2020;46(5):919-929. doi:10.1007/s00134-019-05900-x
February 2020
Hypertonic Saline is Superior to Mannitol for the Combined Effect on Intracranial Pressure and Cerebral Perfusion Pressure Burdens in Patients With Severe Traumatic Brain Injury
Halinder S Mangat, Xian Wu, Linda M Gerber, Justin T Schwarz, Malik Fakhar, Santosh B Murthy, Philip E Stieg, Jamshid Ghajar, Roger Härtl
Neurosurgery. 2020;86(2):221-230. doi:10.1093/neuros/nyz046
January 2020
Concussion Guidelines Step 2: Evidence for Subtype Classification
Angela Lumba-Brown, MD, Masaru Teramoto, PhD, MPH, O Josh Bloom, MD, MPH, David Brody, MD, PhD, James Chesnutt, MD, James R Clugston, MD, MS, Michael Collins, PhD, Gerard Gioia, PhD, Anthony Kontos, PhD, Avtar Lal, PhD, Allen Sills, MD, Jamshid Ghajar, MD, PhD
Neurosurgery. 2020;86(1):2-13. doi:10.1093/neuros/nyz332
November 2019
Representation of Concussion Subtypes in Common Postconcussion Symptom-rating Scales
Angela Lumba-Brown, Jamshid Ghajar, Jordan Cornwell, O Josh Bloom, James Chesnutt, James R. Clugston, Raina Kolluri, John J. Leddy, Masaru Teramoto & Gerard Gioia Future Medicine. 2019 Nov. 1 https://doi.org/10.2217/cnc-2019-0005
September 2018
Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children
Lumba-Brown, A., Yeates, K.O., Sarmiento. K., Breiding, M.J., Haegerich, T.M., & Gioia, G.A., et al.
Published online September 4, 2018. doi:10.1001/jamapediatrics.2018.2853
September 2018
Diagnosis and Management of Mild Traumatic Brain Injury Amoung Children: A Systematic Review
Lumba-Brown, A., Yeates, K.O., Sarmiento. K., Breiding, M.J., Haegerich, T.M., & Gioia, G.A., et al.
JAMA Pediatr. Published online September 4, 2018
July 2018
Association of Visual Tracking Metrics With Post-concussion Symptomatology
Maruta J, Spielman LA, Rajashekar U, Ghajar J. Front Neurol. 2018 Jul 26;9:611. doi: 10.3389/fneur.2018.00611. eCollection 2018. PMID: 30093880
June 2018
Development of the CIDSS2 Score for Children with Mild Head Trauma without Intracranial Injury
Greenberg JK, Yan Y, Carpenter CR, Lumba-Brown A, Keller MS, Pineda J, Brownson RC, Limbrick D. J Neurotrauma. 2018 Jun 8. doi: 10.1089/neu.2017.5324. PMID: 29882466
March 2018
The Effect of Physical Exercise After a Concussion: A Systematic Review and Meta-analysis
Lal A, Kolakowsky-Hayner SA, Ghajar J, Balamane M. Am J Sports Med. 2018 Mar;46(3):743-752. doi: 10.1177/0363546517706137. Epub 2017 Jun 1. PMID: 28570092
April 2017
Development and Internal Validation of a Clinical Risk Score for Treating Children With Mild Head Trauma and Intracranial Injury
Greenberg JK, Yan Y, Carpenter CR, Lumba-Brown A, Keller MS, Pineda JA, Brownson RC, Limbrick DD. JAMA Pediatr. 2017 Apr 1;171(4):342-349. doi: 10.1001/jamapediatrics.2016.4520. PMID: 28192567
March 2017
Frequency Responses to Visual Tracking Stimuli May Be Affected by Concussion
Maruta J, Jaw E, Modera P, Rajashekar U, Spielman LA, Ghajar J. Mil Med. 2017 Mar;182(S1):120-123. doi: 10.7205/MILMED-D-16-00093. PMID: 28291462
January 2017
Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition
Carney N, Totten AM, O'Reilly C, Ullman JS, Hawryluk GW, Bell MJ, Bratton SL, Chesnut R, Harris OA, Kissoon N, Rubiano AM, Shutter L, Tasker RC, Vavilala MS, Wilberger J, Wright DW, Ghajar J. Neurosurgery. 2017 Jan 1;80(1):6-15. doi: 10.1227/NEU.0000000000001432. PMID: 27654000