Spring 2016 BioEngineering 229/Radiology 222C

Instructors

Assistant Professor (Research) of Radiology (Molecular Imaging)
Professor of Pediatrics (Neonatology), Emeritus
Professor of Pediatrics (Neonatology), Emeritus
Professor of Pediatrics (Neonatology), Emeritus
Professor of Radiology (Radiological Sciences Lab)
Sr Res Scientist-Basic Life, Rad/Molecular Imaging Program at Stanford
Assistant Professor of Radiation Oncology (Radiation Physics)
Professor of Otolaryngology-Head and Neck Surgery and of Radiology (Molecular Imaging Program at Stanford)
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Course Logistics


Classes: Mondays and Fridays 9:30-11:20 AM
M114 Alway Building
Reference
Materials:


At Lane Library

Molecular Imaging: Principles and Practice
Weissleder R, Ross BD, Rehemtulla A, Gambhir SS
2010 People's Medical Publishing House

Exams: Midterm and final exams consist of a proposal review (midterm) and a written proposal (final)
Proposal to review
Critique Template
Grading: Class participation (30%)
Midterm exam—review a proposal (30%)
Final exam—write a proposal (40%)

Course Syllabus


Week Monday Instructor Friday Instructor
1 3/28

Parcels of molecular data in cellular communication: imaging exosome function

C. Contag

 Lecture notes

 Kanada M. Differential fates of biomolecules delivered to target cells via extracellular vesicles. PNAS 2015;112(12):E1433-42.
 Kanada M. Signaling by Extracellular Vesicles Advances Cancer Hallmarks.Trends in Cancer. 2016;2(2):84-94.

4/1

Parcels of molecular data in cellular communication: imaging exosome function

C. Contag

 Lecture notes

2 4/4

Multimodality Imaging of Glutamate for Cancer Diagnosis and Therapy

E. Mittra

 Lecture notes

 Choi C. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in subjects with IDH-mutated gliomas. Nat Med. 2012;18(4):624-30
 Hensley C. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest. 2013 Sep;123(9):3678-84.
 Keshari K.Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imagings.PNAS 2011 Nov 15;108(46):18606-11.
 Koglin N. Specific PET Imaging of xC- Transporter Activity Using a 18 F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism. Clin Cancer Res. 2011 Sep 15;17(18):6000-11.
 Takeuchi S. Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas. Neurosurgery. 2013 Jan;72(1):33-41.

4/8

Multimodality Imaging of Glutamate for Cancer Diagnosis and Therapy

E. Mittra

 Lecture notes

3 4/11

Neural Dynamics and Glymphatics (Stains and Drains in Brains) - Is It All a Wash?

M. Moseley

 Lecture notes

4/15

Neural Dynamics and Glymphatics (Stains and Drains in Brains) - Is It All a Wash?

M. Moseley

 Lecture notes

4 4/18

Imaging agents in robotic surgery

J. Sorger

 Lecture notes

 Hu JC. Temporal trends in radical prostatectomy complications from 1991 to 1998. J Urol. 2003 Apr;169(4):1443-8.
 Holland CM. Radical hysterectomy. Best Pract Res Clin Obstet Gynaecol. 2005 Jun;19(3):387-401.
 Lanfranco AR. Robotic surgery: a current perspective.Ann Surg. 2004 Jan;239(1):14-21.
 Ramirez D. Robotic-assisted laparoscopic prostatectomy: An update on functional and oncologic outcomes, techniques, and advancements in technology. J Surg Oncol. 2015 Dec;112(7):746-52.
 Sinha R. Robotic surgery in gynecology. J Minim Access Surg. 2015 Jan-Mar;11(1):50-9.
 Daskalaki D.Fluorescence in robotic surgery. J Surg Oncol. 2015 Sep;112(3):250-6.

4/22

Imaging agents in robotic surgery

J. Sorger
5 4/25

Image-guided surgery

E. Rosenthal

 Lecture notes

 de Boer E. A standardized light-emitting diode device for photoimmunotherapy. JNM 2014 Nov;55(11):1893-8.
 Mitsunaga M. Near-infrared theranostic photoimmunotherapy (PIT): repeated exposure of light enhances the effect of immunoconjugate. Bioconjug Chem. 2012 Mar 21;23(3):604-9.
 Sato K.Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor. Mol Oncol. 2014 May;8(3):620-32.

4/29

Image-guided surgery

E. Rosenthal

 

Midterm Exam Materials

Proposal to review
Critique Template

 

 

6 5/2

Nanoprobes for diagnosis and imaging

S. Park

 Lecture notes

 James M. A molecular imaging primer: modalities, imaging agents, and applications. Physiol Rev. 2012 Apr;92(2):897-965.

5/6

Nanoprobes for diagnosis and imaging

S. Park
7 5/9

Follow that cell! New frontiers in cell tracking

G. Pratx

 Lecture notes

 Kircher MF.Noninvasive cell-tracking methods. Nat Rev Clin Oncol. 2011 Sep 27;8(11):677-88.
 Rogers WJ.Technology insight: in vivo cell tracking by use of MRI. Nat Clin Pract Cardiovasc Med. 2006 Oct;3(10):554-62.
 Zhang SJ.Comparison of imaging techniques for tracking cardiac stem cell therapy. JNM. 2007 Dec;48(12):1916-9.

5/13

Follow that cell! New frontiers in cell tracking

G. Pratx
8 5/16

Clinical Photoacoustic Imaging: Hype or Hope?

R. Kothapalli

 Garcia-Uribe A. Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer. Sci Rep. 2015 Oct 29;5:15748.
 Stoffels I. Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging. Sci Transl Med. 2015 Dec 9;7(317):317ra199.
 Zackrisson S. Light in and sound out: emerging translational strategies for photoacoustic imaging. Cancer Res. 2014 Feb 15;74(4):979-1004.

5/20

Clinical Photoacoustic Imaging: Hype or Hope?

R. Kothapalli
9 5/23

 

Novel PET-MR Imaging Strategies for Studying Living Subjects

F. Chin

 

 Lecture notes

 de Galiza Barbosa F.Multi-technique hybrid imaging in PET/CT and PET/MR: what does the future hold? Clin Radiol. 2016 Apr 21. pii: S0009-9260(16)30001-0. 
 Barthel H. PET/MR in dementia and other neurodegenerative diseases.Semin Nucl Med. 2015 May;45(3):224-33. 
 Fraum TJ. PET/MRI: Emerging Clinical Applications in Oncology. Acad Radiol. 2016 Feb;23(2):220-36. 
 Gaertner FC. PET/MR: a paradigm shift. Cancer Imaging. 2013 Feb 27;13:36-52. 
 Disselhorst JA.Principles of PET/MR Imaging.JNM 2014 May 12;55(Supplement 2):2S-10S. 
 Queiroz MA. PET/MR in cancers of the head and neck. Semin Nucl Med. 2015 May;45(3):248-65. 
 Torigian DA. PET/MR imaging: technical aspects and potential clinical applications.Radiology. 2013 Apr;267(1):26-44.

5/27

 

Novel PET-MR Imaging Strategies for Studying Living Subjects

F. Chin

 

 Ganji A. Aptamers: new arrows to target dendritic cells. J Drug Target. 2016;24(1):1-12. 
 Gijs M. Aptamers as radiopharmaceuticals for nuclear imaging and therapy.Nucl Med Biol. 2016 Apr;43(4):253-71. 
 Oh SS. Synthetic Aptamer-Polymer Hybrid Constructs for Programmed Drug Delivery into Specific Target Cells. J Am Chem Soc. 2014 Oct 22;136(42):15010-5. 
 Pei X. Clinical applications of nucleic acid aptamers in cancer (Review).Mol Clin Oncol. 2014 May;2(3):341-348. 
 Sandiford L. The Use of Contrast Agents in Clinical and Preclinical PET-MR Imaging. PET Clin. 2016 Apr;11(2):119-28. 
 Sun H.Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy. Mol Ther Nucleic Acids. 2014 Aug 5;3:e182. 
 Wang J. Particle display: a quantitative screening method for generating high-affinity aptamers. Angew Chem Int Ed Engl. 2014 May 5;53(19):4796-801. 
 Yüce M. Trends in aptamer selection methods and applications. Analyst. 2015 Aug 21;140(16):5379-99.

10 5/30 Holiday
Final exams June 3-8, 2016