Stanford Center for Children's Brain Tumors
Unlocking the Genetic Code for Medulloblastoma Brain TumorsOne exciting example of the several ongoing research projects sponsored by the CCBT includes Dr. Matthew Scott and colleagues who discovered in 1996 that mutations in the Hedgehog receptor gene PATCHED (top image) affected normal development of the cerebellar granule layer precursor cells which resulted in the formation of medulloblastoma tumors. They then genetically engineered a mouse model of the disease by constructing a mutant patched1 mouse (bottom image). Present avenues of research will apply genome sequencing of mouse medulloblastoma tumor tissue compared to adjacent non-tumor normal cerebellum. The second phase will include similar sequencing in human medulloblastoma and cerebellum. The third phase will be to monitor the progression of tumors by examining early pre-tumors for genetic lesions. In collaboration with Chris Contag, Ph.D. and the Molecular Imaging Program at Stanford (MIPS) the pediatric neurosurgery team is evaluating the feasibility of improving medulloblastoma tumor resections by labeling the cells with novel peptides and using a hand-held confocal microscope to visualize residual cells at the tumor margin.
Brain Tumor Center at Lucile Packard Children's Hospital
At Lucile Packard Children’s Hospital Stanford, young patients receive the best available care from a top-rated team of caring surgeons, neurologists, neuro oncologists, psychologists, psychiatrists, nurses, and social workers, who collaborate to achieve the best possible medical outcome and quality of life for each patient.