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  1. Study finds infusion of young blood recharges brains of old mice

    Wyss-Coray and his collaborators are working to discover the specific factors in the blood of young mice that can recharge the brain of an old mouse.

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  2. Study finds gene variant puts women at higher risk of Alzheimer’s than it does men

    Michael Greicius and his team have found that women who carry a copy of a gene variant called ApoE4 have a substantially greater risk of developing Alzheimer's. 

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  3. Study finds DNA of peanut-allergic kids changes with immune therapy

    Research led by immunologist Kari Nadeau shows a blood test could determine whether patients who have been desensitized to their peanut allergies need to continue eating peanuts daily to retain their tolerance.

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  4. A hydrogel process developed at Stanford creates transparent brain

     

    Bioengineer Karl Deisseroth develops CLARITY, a process that renders brain tissue from mice transparent, allowing the entire brain structure and its wiring to be studied.

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  5. A new technique induces egg growth in infertile women, and one gives birth

    An in-vitro activation procedure developed by endocrinologist Aaron Hsueh is used to induce egg growth in some infertile women, and one gives birth.

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  6. Michael Levitt, PhD, wins the Nobel Prize in Chemistry

  7. Thomas Südhof, MD, wins the Nobel Prize in Physiology or Medicine

  8. First-ever integrative 'omics' profile lets scientist discover, track his diabetes onset

    Geneticist Michael Snyder integrates a deep analysis of his DNA, RNA and the proteins in his cells; the analysis correctly predicts that he will develop diabetes.

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  9. Use of a single antibody caused human tumors transplanted into laboratory mice to disappeared or shrink

    Pathologist Irving Weissman shows that a single antibody, which counters the effect of the CD47 molecule, shrinks a variety of human tumors transplanted into mice.

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  10. New method allows sequencing of fetal genomes using maternal blood

    Bioengineer Stephen Quake develops a groundbreaking method to sequence the genome of an unborn baby using only a blood sample from the mother.

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  11. Brian Kobilka, MD, wins the Nobel Prize in Chemistry

  12. Lloyd B. Minor, MD, becomes Dean of the School of Medicine

  13. Using skin cells from patients with a severe genetic heart defect, researchers create human heart cells with the same genetic mutation, allowing them to test drugs on the cells

    Using skin cells from patients with a severe genetic heart defect, neurobiologist Ricardo Dolmetsch creates human heart cells with the same genetic mutation, allowing his team to test drugs on the cells.

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  14. Scientists demonstrate that elevating the brain's susceptibility to stimulation can produce social deficits resembling those of autism and schizophrenia

    Bioengineer Karl Deisseroth uses the optogenetic technique in mice to switch on and off the social-behavior deficits that resemble those in humans with autism and schizophrenia.

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  15. Stanford/Packard scientists find new uses for existing drugs by mining gene-activity data banks

    Studies by Marina Sirota, Joel Dudley and Atul Butte demonstrate an approach that could quicken the pace of combating difficult diseases by matching them with drugs that are already approved for other indications.

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  16. First use of aggregate patient data from electronic medical records to select treatment for a rare pediatric condition



    Physicians at Lucile Packard Children's Hospital Stanford use aggregate patient data from electronic medical records to identify the best option for treating a patient with rare disorder.

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  17. Scientists transform mouse skin cells directly into functional nerve cells with the application of just three genes

    Pathologist Marius Wernig turns mouse skin cells into cells that insulate neurons with the application of just three genes.

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  18. For the first time, researchers use a healthy person's complete genome sequence to predict his risk for dozens of diseases

    A team of researchers analyzes bioengineer Stephen Quake's genome, predicting his likelihood of developing heart disease, Alzheimer's and cancer.

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  19. Lorry I. Lokey Stem Cell Research Building opens

  20. Li Ka Shing Center for Learning and Knowledge opens

  21. Discovery of a "don't-eat-me" signal that allows blood cancer stem cells to migrate safely through the body

    A team of researchers led by Irving Weissman discovers that leukemia stem cells evade detection by mimicking normal cells and moving safely within the body.

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  22. Discovery of the first human bladder cancer stem cell

    Pathologist Irving Weissman identifies the stem cell that gives rise to bladder cancer, and also shows how the cell uses the "don't-eat-me" signal, a molecule known as CD47, to evade the body's defenses.

     

  23. A researcher sequences his own genome for less than $50,000 and with a team of just two others

    A technique developed by bioengineer Stephen Quake enables him to sequencs his own genome for less than $50,000 and with a team of just two others.

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  24. Development of a test that reduces the risks in testing for chromosomal disorders such as Down syndrome

    Bioenginner Stephen Quake and his team develop a method of screening a pregnant woman's blood to identify chromosomal disorders, such as Down syndrome, in her fetus.

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  25. Ground breaking for the Lorry I. Lokey Stem Cell Research Building

  26. Ground breaking for Li Ka Shing Center for Learning and Knowledge

  27. Development of a new type of imaging system that can illuminate tumors in living subjects, getting pictures with a precision of nearly one-trillionth of a meter

    Radiologist Sanjiv Gambhir develops a new type of imaging system that can illuminate tumors in living subjects with a precision of nearly one-trillionth of a meter

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  28. Discovery of a molecule that kills kidney cancer cells

    Radiation oncologist Amato Giaccia identifies a molecule that kills kidney cancer cells, which could provide new treatment options.

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  29. Identification of a pattern of gene expression shared by transplant patients who are able to stay healthy without anti-rejection drugs

    Pediatric nephrologist Minnie Sarwal finds that kidney transplant recipients with a similar gene-expression pattern were able to eliminate or reduce their dependence on immunosuppressive drugs.

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  30. Application and expansion of optogenetics, a technique to control brain cell activity with light

    Bioengineer Karl Deisseroth and his team develop a technique known as optogenetics that allows them to genetically alter brain cell activity in mice with light.

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  31. Discovery that stem cells transplanted into the brains of rats and mice navigate toward areas damaged by stroke

    Neurosurgeon Gary Steinberg tracks human stem cells transplated into brain of rats, finding that they  successfully navigate toward areas damaged by stroke.

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  32. Demolition of Fairchild Auditorium for new learning and knowledge center

  33. Andrew Fire, PhD, wins the Nobel Prize in Physiology or Medicine

  34. Roger Kornberg, PhD, wins the Nobel Prize in Chemistry

  35. Discovery of a protein that may explain why tumors in a low-oxygen environment are so deadly

    Radiation oncologist Amato Giaccia identifies a  protein called lysyl oxidase that, when found in a low-oxygen environment, may cause fast-spreading cancers.

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  36. Discovery of obestatin, a hormone that suppresses appetite

    Endocrinologist Aaron Hsueh discovers obestatin, a hormone that supresses appetite and may lead to treatments for obesity.

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  37. Stanford Cancer Center opens

  38. The Clark Center (Bio-X) building and the underground parking garage on Pasteur Drive opens

  39. Discovery that Wnt genes, first discovered as critical genes in cancer, are also critical regulators of stem cell development

    Developmental biologist Roeland Nusse isolates a group of proteins called Wnts that help keep stem cells in their youthful state.

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  40. Discovery that training exercises can physically change the way the brain is wired

  41. Creation of the Stanford Institute for Cancer/Stem Cell Biology and Medicine, a multidisciplinary effort to develop novel treatments for cancer and other diseases

  42. First use of gene expression profiling to predict cancer outcomes

  43. First use of RNAi to switch off genes in mice

    Geneticist Mark Kay uses a gene-therapy technique known as RNA inihibition to switch off genes in mice, which could point toward development treatments for cancer, hepatitis C and AIDS.

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  44. Ground breaking for new cancer center

  45. Ground breaking and construction begins for new Clark Center (Bio-X) building

  46. Philip A. Pizzo, MD, becomes Dean of the School of Medicine

  47. Identification of a novel gene family involved in asthma

    In a study in mice, researcher Rosemarie DeKruyff identifies a gene family that may underlie the development of asthma.

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  48. Participation in the successful international effort to complete the human genome sequencing project

    Teams headed by geneticist Richard Myers and biochemist Ronald Davis help sequence the human genome.

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  49. Center for Clinical Sciences Research building opens

  50. First use of gene expression profiling to distinguish cancer sub-types

  51. Discovery of hereditary arthritis gene

    Developmental biologist David Kingsley discovers that a gene that transports pyrophosphate into cells  may regulate the development of arthritis in humans and animals.

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  52. Solution of the structure of the RNA polymerase protein, a pivotal molecule that copies genes from DNA to RNA

    Structural biologist Roger Kornberg shows the structure of the RNA polymerase protein, a step in the transfer of information from gene to protein. The discovery will later earn Kornberg the 2006 Nobel Prize in Chemistry.

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  53. Stanford Hospital & Clinics and Lucile Packard Children’s Hospital returns to independent status ending a two-year merger with UCSF Medical Center

  54. Discovery of a genetic mutation that causes narcolepsy, a disabling sleep disorder affecting humans and animals

    Sleep researcher Emmanuel Mignot identifies the defective gene that causes narcolepsy, a disabling sleep disorder affecting humans and animals.

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  55. First experimental demonstration that limiting children’s television use prevents excess weight gain

    Pediatrician Thomas Robinson finds that children who curtailed their television time gained significantly less body fat than those who didn't .

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  56. Merger of the University of California-San Francisco Medical Center and UCSF/Mount Zion Medical Center with Stanford Hospital & Clinics and Lucile Packard Children’s Hospital to create UCSF Stanford Health Care, a private nonprofit organization

  57. Ground breaking for the new Center for Clinical Sciences Research

  58. Lucile Packard Children’s Hospital at Stanford board of directors transfers control of the facility to Stanford Health Services; Packard Children’s Hospital remains a separately licensed nonprofit corporation

  59. Completion of a multicenter trial showing that standard chemotherapy for most children with early-stage non-Hodgkin’s lymphoma can be safely reduced

    Pediatric oncologist Michael Link leads a study that shows chemotherapy can be reduced by two-thirds in children with early-stage non-Hodgkin's lymphoma with no negative consequences.

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  60. First optical imaging of gene expression in vivo

    Christopher Contag develops a technique to detect light emitted when certain genes are activated in a living animal model.

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  61. Discovery that mutations in a single gene are responsible for the most common form of skin cancer in humans

    Developmental biologist Matthew Scott and a team at UC-San Francisco discover that a defect in the hedgehog gene causes basal cell carcinoma.

     

  62. Discovery that the p53 protein, known to be involved in controlling cancerous tumors, works as an “emergency brake” on cancer development

    Oncologist Amato Giaccia and his colleagues find that the p53 protein, known to be involved in controlling cancerous tumors, can help halt cancer development.

    Read more about Dr. Amato Giaccia (PDF)

     

  63. Eugene A. Bauer, MD, becomes Dean of the School of Medicine

  64. First optical imaging of infection in vivo

    Christpher Contag and David Benaron develop optical imaging that allows researchers to detect and track bioluminescent bacteria in mice.

     

  65. Development of the microarray technology that allows researchers to see at once which genes of the thousands present in a cell are switched “on”

    Biochemist Pat Brown and colleagues develop microarrays, or gene chips, that allow researchers to analyze the activity of thousands of genes in a cell at once.

    Read more about Dr. Pat Brown (PDF)

     

  66. Creation of Stanford Health Services through the merger of Stanford University Hospital and Stanford University Clinic

  67. Development of the new diagnostic instrument for rapid bedside screening of hemolysis in jaundiced newborns

    Neonatologist David Stevenson develops a diagnostic instrument that provides rapid bedside screening for the breakdown of red blood cells in jaundiced newborns.

     

  68. Development of a technique that enables researchers to toggle genes on and off in experimental animals

    Pathologist Gerald Crabtree develops techniques that allow scientists to toggle genes on and off in animal models.

     

  69. First demonstration that lifestyle changes and drug therapy decrease heart attack rates and slows progression of atherosclerosis in coronary arteries

    Researcher William Haskell shows that intensive lifestyle changes and  prevention/treatment programs can reduce cardiac events and slow the progression of atherosclerosis in coronary arteries.

     

  70. First clinical trial testing methods for preventing eating disorders in adolescents

    Researchers Joel Killen and Thomas Robinson publish findings that shed light on the causes of eating disorders in adolescents.

     

     

  71. Department of Psychiatry and Behavioral Sciences's new building on Quarry Road opens

  72. Stanford University Clinic's new outpatient building on Blake Wilbur Drive opens

  73. First functional image using time-resolved optics

    Researchers produce the first functional image using time-resolved, near-infrared light.

     

  74. Stanford University Medical Center's new 780-space parking garage opens

  75. Richard M. Lucas Center for Magnetic Resonance Spectroscopy and Imaging opens

  76. Discovered the gene underlying a group of diseases called the demyelinating peripheral neuropathies in which the protective covering on nerves breaks down and the nerves are unable to function properly

    Neurobiologist Eric Shooter finds a gene involved in nerve disorders in which the protective covering on nerves breaks down. 

    Read more about Dr. Shooter (PDF)

     

  77. Development of a genetically engineered vaccine to enhance patients’ immunological response against B-cell lymphoma

    Oncologist Ron Levy develops a cancer vaccine that could prevent recurrrent lymphomas in patients treated with chemotherapy.

     

  78. Lucile Packard Children’s Hospital at Stanford opens

  79. Discovery of “off-switch” for genetic reproduction in bacteria

    Biochemist Arthur Kornberg finds a chemical impulse that turns off the reproductive machinery in the chromosomes of E. coli bacteria.

     

  80. Beckman Center for Molecular and Genetic Medicine opens

  81. Stanford University Hospital opens new wing, the first major modernization project since 1959

  82. Discovery of the “homing receptor,” which guides white blood cells into the peripheral lymph nodes

    Pathologist Eugene Butcher discovers a receptor that guides white blood cells into the peripheral lymph nodes.

     

  83. Development of an animal model for studying the human immune system

    Researchers Irving Weissman and Mike McCune create an animal model that can be used to study a variety of human diseases.

  84. Ground breaking for the Lucile Packard Children’s Hospital at Stanford

  85. Isolation of pure hematopoietic stem cells from mice

    Pathologist Irving Weissman isolates a rare mouse cell, known as the hematopoetic stem cell, which gives rise to all the cells of the blood and immune systems.

  86. Naming of the Center for Molecular and Genetic Medicine in honor of philanthropists Arnold and Mabel Beckman

  87. Remodel and modernization of Stanford University Clinic

  88. David Korn, MD, becomes Dean of the School of Medicine

  89. Isolation of a gene coding for part of the T-cell receptor, a key to the immune system’s function

    Immunologist Mark Davis characterizes the T-cell receptor, believed to regulate the body's response to infectious agents and cancerous diseases.

    More about Dr. Mark Davis (PDF)

  90. Renaming of outpatient clinics to Stanford University Clinic

  91. Development with UC-San Diego of the first human monoclonal antibody for treating septic shock

    Stanford's Henry Kaplan and Nelson Teng and colleagues at UC-San Diego develop the first human monoclonal antibody for treating overwhelming infections.

  92. Dominick P. Purpura, MD, becomes Dean of the School of Medicine

  93. Stanford University Hospital embarks on a major modernization program to promote and expand facilities; signs agreement with Children’s Hospital at Stanford for consolidation of all pediatric services in the new Lucile Packard Children’s Hospital

  94. First report of successful use of monoclonal antibodies to treat cancer

    Oncologist Ronald Levy reports the first successful use of monoclonal antibodies, which are laboratory-created molecules engineered to attach to specific defects in cancer cells.

     

  95. First successful human combined heart/lung transplant in the world (fourth attempted worldwide)

    Mary Gohlke receives the world's first combined heart and lung transplant in a landmark operation led by surgeon Bruce Reitz.

     

  96. First creation of human hybridoma cell line

    Henry Kaplan and Lennart Olsson create cells to manufacture human antibodies for the improved diagnosis and treatment of diseases.

    Read full story (PDF)

  97. Paul Berg, PhD, wins the Nobel Prize in Chemistry

  98. Children’s Hospital at Stanford opens a new wing, consolidating all pediatric outpatient services of Stanford University Medical Center

  99. Discovery of dynorphin, a brain chemical 200 times more powerful than morphine

    Pharmacologist Avram Goldstein discovers a chemical in the human brain that could lead to the development of powerful painkillers with fewer undesirable side effects.

    Read full story (PDF)

  100. Discovery of link between exercise and increased “good” (HDL) cholesterol levels

    John Farquhar and Peter Wood demonstrate that exercise is associated with an increase in "good" cholesterol levels, and can decrease the likelihood of coronary problems.

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